Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer

Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer

Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevalence of 35%. However, despite the frequent recurren...

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Bibliographic Details
Main Authors: Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-57854-w

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https://doi.org/10.1038/s41598-024-57854-w

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