Assessment of Thermal Stability of Mutant p53 Proteins via Differential Scanning Fluorimetry

Assessment of Thermal Stability of Mutant p53 Proteins via Differential Scanning Fluorimetry

The p53 protein is a transcription factor that preserves the integrity of the genome. The <i>TP53</i> gene has inactivating mutations in about 50% of all human cancers. Some missense mutations lead to decreased thermal stability in the p53 protein, its unfolding and aggregation under phy...

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Bibliographic Details
Main Authors: Raniya Khadiullina, Regina Mirgayazova, Damir Davletshin, Elvina Khusainova, Vitaly Chasov, Emil Bulatov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Life
Subjects:
p53
transcription factor
mutant
melting temperature
differential scanning fluorimetry
Online Access:https://www.mdpi.com/2075-1729/13/1/31

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https://www.mdpi.com/2075-1729/13/1/31

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