Assessment of Thermal Stability of Mutant p53 Proteins via Differential Scanning Fluorimetry
The p53 protein is a transcription factor that preserves the integrity of the genome. The <i>TP53</i> gene has inactivating mutations in about 50% of all human cancers. Some missense mutations lead to decreased thermal stability in the p53 protein, its unfolding and aggregation under phy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/1/31 |