Activation of the <italic toggle="yes">Listeria monocytogenes</italic> Virulence Program by a Reducing Environment

Activation of the <italic toggle="yes">Listeria monocytogenes</italic> Virulence Program by a Reducing Environment

ABSTRACT Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional regulator PrfA. Here, we report that robus...

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Bibliographic Details
Main Authors: Jonathan L. Portman, Samuel B. Dubensky, Bret N. Peterson, Aaron T. Whiteley, Daniel A. Portnoy
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
glutathione
c-di-AMP
gram-positive bacteria
stringent response
virulence
virulence regulation
Online Access:https://journals.asm.org/doi/10.1128/mBio.01595-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01595-17

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