W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state
Abstract Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme biosynthesis. Within the transport pathway, a conserved aromatic residue W546 located in each monomer plays a pivotal rol...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05339-3 |