Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity

Antibody–drug conjugates (ADCs) constitute a rapidly expanding category of biopharmaceuticals that are reshaping the landscape of targeted chemotherapy. The meticulous process of selecting therapeutic targets, aided by specific monoclonal antibodies’ high specificity for binding to designated antige...

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Bibliographic Details
Main Authors: Emenike Kenechi Onyido, David James, Jezabel Garcia-Parra, John Sinfield, Anna Moberg, Zoe Coombes, Jenny Worthington, Nicole Williams, Lewis Webb Francis, Robert Steven Conlan, Deyarina Gonzalez
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antibodies
Subjects:
ovarian cancer
antibody–drug conjugates
bioinformatics
in silico
biomarkers
therapeutics
Online Access:https://www.mdpi.com/2073-4468/12/4/65

Internet

https://www.mdpi.com/2073-4468/12/4/65

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