Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2

Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2

B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that mediates the escape of tumor cells from immunosurveillance. Consequently, BTLA and its ligand herpesvirus entry mediator (HVEM) are potentially immunotherapeutic targets. However, the potential effects of BTLA on tumor cells...

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Bibliographic Details
Main Authors: Tian-You Cheng, Ya-Juan Liu, Hong Yan, Yi-Bo Xi, Li-Qiang Duan, Yang Wang, Tian-Tian Zhang, Yin-Min Gu, Xiao-Dong Wang, Chang-Xin Wu, Shan Gao
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
immune checkpoint
tumor cell-intrinsic BTLA
tumor cell-intrinsic HVEM
tumor suppressor
therapeutic target
Online Access:https://www.mdpi.com/2073-4409/11/24/4021

Internet

https://www.mdpi.com/2073-4409/11/24/4021

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