Complete Genome Sequencing of Tick-Borne Encephalitis Virus Directly from Clinical Samples: Comparison of Shotgun Metagenomic and Targeted Amplicon-Based Sequencing

Complete Genome Sequencing of Tick-Borne Encephalitis Virus Directly from Clinical Samples: Comparison of Shotgun Metagenomic and Targeted Amplicon-Based Sequencing

The clinical presentation of tick-borne encephalitis virus (TBEV) infection varies from asymptomatic to severe meningoencephalitis or meningoencephalomyelitis. The TBEV subtype has been suggested as one of the most important risk factors for disease severity, but TBEV genetic characterization is dif...

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Bibliographic Details
Main Authors: Samo Zakotnik, Nataša Knap, Petra Bogovič, Tomaž Mark Zorec, Mario Poljak, Franc Strle, Tatjana Avšič-Županc, Miša Korva
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
tick-borne encephalitis virus
whole genome sequencing
amplicons
metagenomics
next-generation sequencing (NGS)
clinical samples
Online Access:https://www.mdpi.com/1999-4915/14/6/1267

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https://www.mdpi.com/1999-4915/14/6/1267

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