Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome

Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome

Megalin/LRP2 is the primary multiligand receptor for the re-absorption of low molecular weight proteins in the proximal renal tubule. Its function is significantly dependent on its endosomal trafficking. Megalin recycling from endosomal compartments is altered in an X-linked disease called Lowe Synd...

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Bibliographic Details
Main Authors: Lisette Sandoval, Luz M. Fuentealba, María-Paz Marzolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
megalin
lowe syndrome
ocrl1
APPL1
renal disease
proteolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.911664/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.911664/full

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