Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences

Abstract The experience of adversity in childhood has been associated with poor health outcomes in adulthood. In search of the biological mechanisms underlying these effects, research so far focused on alterations of DNA methylation or shifts in transcriptomic profiles. The level of protein, however...

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Bibliographic Details
Main Authors: Johannes C. S. Zang, Caroline May, Birte Hellwig, Dirk Moser, Jan G. Hengstler, Steve Cole, Markus Heinrichs, Jörg Rahnenführer, Katrin Marcus, Robert Kumsta
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02320-w