The Challenges of Recombinant Endostatin in Clinical Application: Focus on the Different Expression Systems and Molecular Bioengineering

The Challenges of Recombinant Endostatin in Clinical Application: Focus on the Different Expression Systems and Molecular Bioengineering

Angiogenesis plays an essential role in rapid growing and metastasis of the tumors. Inhibition of angiogenesis is a putative strategy for cancer therapy. Endostatin (Es) is an attractive anti-angiogenesis protein with some clinical application challenges including; short half-life, instability in se...

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Bibliographic Details
Main Authors: Abbas Mohajeri, Sarvin Sanaei, Farhad Kiafar, Amir Fattahi, Majid Khalili, Nosratollah Zarghami
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2017-04-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Endostatin
Angiogenesis
Expression system
Bioengineering
Molecular targeted therapy
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-21.pdf

Internet

http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-21.pdf

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