Simultaneous Determination of Selegiline, Desmethylselegiline, R/S-methamphetamine, and R/S-amphetamine on Dried Urine Spots by LC/MS/MS: Application to a Pharmacokinetic Study in Urine

Simultaneous Determination of Selegiline, Desmethylselegiline, R/S-methamphetamine, and R/S-amphetamine on Dried Urine Spots by LC/MS/MS: Application to a Pharmacokinetic Study in Urine

Objective: Chiral analysis is a crucial method to differentiate selegiline intake from drug abuse. A dried urine spot (DUS) analytical method based on spotting urine samples (10 μL) onto dried spot collection cards, and followed by air-drying and extraction, was developed and validated for the deter...

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Bibliographic Details
Main Authors: Lizhu Chen, Yingjia Yu, Gengli Duan, Xin Wang, Baohua Shen, Ping Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Chemistry
Subjects:
urine
chiral analysis
pharmacokinetic
R/S-methamphetamine
R/S-amphetamine
selegiline
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00248/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00248/full

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