How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations.

How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations.

Cholesteryl ester transfer protein (CETP) mediates the reciprocal transfer of neutral lipids (cholesteryl esters, triglycerides) and phospholipids between different lipoprotein fractions in human blood plasma. A novel molecular agent known as anacetrapib has been shown to inhibit CETP activity and t...

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Bibliographic Details
Main Authors: Tarja Äijänen, Artturi Koivuniemi, Matti Javanainen, Sami Rissanen, Tomasz Rog, Ilpo Vattulainen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4238956?pdf=render

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http://europepmc.org/articles/PMC4238956?pdf=render

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