The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents

The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents

Abstract MGMT-promoter methylation is associated with favorable outcome in glioblastoma. The aim of this study was to determine whether the absolute number of methylated Cytosine-Guanine-dinucleotide-(CpG-)sites within the DMR-2 island of the MGMT-promoter may correlate with outcome in a qualitative...

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Bibliographic Details
Main Authors: Sebastian Siller, Michael Lauseker, Philipp Karschnia, Maximilian Niyazi, Sabina Eigenbrod, Armin Giese, Joerg-Christian Tonn
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Acta Neuropathologica Communications
Subjects:
Glioblastoma
MGMT promoter
Methylation status
Temozolomide
Linear correlation
Methylation-specific polymerase-chain-reaction
Online Access:https://doi.org/10.1186/s40478-021-01134-5

Internet

https://doi.org/10.1186/s40478-021-01134-5

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