Transgene expression knock-down in recombinant Modified Vaccinia virus Ankara vectors improves genetic stability and sustained transgene maintenance across multiple passages

Transgene expression knock-down in recombinant Modified Vaccinia virus Ankara vectors improves genetic stability and sustained transgene maintenance across multiple passages

Modified vaccinia virus Ankara is a versatile vaccine vector, well suited for transgene delivery, with an excellent safety profile. However, certain transgenes render recombinant MVA (rMVA) genetically unstable, leading to the accumulation of mutated rMVA with impaired transgene expression. This rep...

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Bibliographic Details
Main Authors: Patrick Neckermann, Madlen Mohr, Martina Billmeier, Alexander Karlas, Ditte R. Boilesen, Christian Thirion, Peter J. Holst, Ingo Jordan, Volker Sandig, Benedikt Asbach, Ralf Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
MVA
poxviral vectors
Modified Vaccinia Ankara
transgene stability
transgene knock-down
viral vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1338492/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1338492/full

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