Clinical Utility of Droplet Digital PCR to Monitor BCR-ABL1 Transcripts of Patients With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Post-chimeric Antigen Receptor19/22 T-Cell Cocktail Therapy

Clinical Utility of Droplet Digital PCR to Monitor BCR-ABL1 Transcripts of Patients With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Post-chimeric Antigen Receptor19/22 T-Cell Cocktail Therapy

Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) accounts for 20–30% of adult patients with ALL, characterized by translocation of t(9, 22). Tyrosine kinase inhibitors (TKIs) have significantly improved the outcome even though there are still some problems including relapse du...

Full description

Bibliographic Details
Main Authors: Yuqi Guan, Meilan Zhang, Wei Zhang, Jiachen Wang, Kefeng Shen, Kai Zhang, Li Yang, Liang Huang, Na Wang, Min Xiao, Jianfeng Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
droplet digital PCR
CAR19/22 T-cell cocktail
minimal residual disease
relapsed/refractory
acute lymphoblastic leukemia
Philadelphia chromosome positive
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.646499/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.646499/full

Similar Items