The Common Acid Sphingomyelinase Polymorphism p.G508R is Associated with Self-Reported Allergy

The Common Acid Sphingomyelinase Polymorphism p.G508R is Associated with Self-Reported Allergy

Background: Acid sphingomyelinase (ASM) is a key regulator of ceramide-dependent signalling pathways. Among others, activation of ASM can be induced by CD95 or cytokine signalling and by cellular stress resulting from inflammation or infection. Increased ASM activity was observed in a variety of hum...

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Bibliographic Details
Main Authors: Martin Reichel, Tanja Richter-Schmidinger, Christiane Mühle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, Johannes Kornhuber
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Acid sphingomyelinase
Allergy
Ceramide
Chronic disease
General health
Infection
Inflammation
Online Access:http://www.karger.com/Article/FullText/362986

Internet

http://www.karger.com/Article/FullText/362986

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