Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1α and pERK1/2

Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1α and pERK1/2

Loss of pancreatic beta-cells by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the diabetes mellitus. To this end, we report that curcumin prevents high glucose (HG) induced oxidative stress and apoptosis in mouse pancreatic...

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Bibliographic Details
Main Authors: Kaijian Hou, Yongru Chen, Dan Zhu, Genben Chen, Fengwu Chen, Ningning Xu, Khan Barkat, Jiehong Zheng, Xi Xie, Rongping Chen
Format: Article
Language:English
Published: IMR Press 2020-06-01
Series:Frontiers in Bioscience-Landmark
Subjects:
diabetes mellitus; pancreatic beta cells
curcumin
apoptosis; oxidative stress
chop; pgc-1αlpha
mapk pathway
Online Access:https://www.imrpress.com/journal/FBL/25/11/10.2741/4887

Internet

https://www.imrpress.com/journal/FBL/25/11/10.2741/4887

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