Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1α and pERK1/2

Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1α and pERK1/2

Loss of pancreatic beta-cells by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the diabetes mellitus. To this end, we report that curcumin prevents high glucose (HG) induced oxidative stress and apoptosis in mouse pancreatic...

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Bibliographic Details
Main Authors: Kaijian Hou, Yongru Chen, Dan Zhu, Genben Chen, Fengwu Chen, Ningning Xu, Khan Barkat, Jiehong Zheng, Xi Xie, Rongping Chen
Format: Article
Language:English
Published: IMR Press 2020-06-01
Series:Frontiers in Bioscience-Landmark
Subjects:
diabetes mellitus; pancreatic beta cells
curcumin
apoptosis; oxidative stress
chop; pgc-1αlpha
mapk pathway
Online Access:https://www.imrpress.com/journal/FBL/25/11/10.2741/4887
Description
Summary:Loss of pancreatic beta-cells by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the diabetes mellitus. To this end, we report that curcumin prevents high glucose (HG) induced oxidative stress and apoptosis in mouse pancreatic beta cells. Moreover, curcumin prevents HG induced increase in expression of CHOP, decrease in PCG-1α and phosphorylation of ERK1/2 (pERK1/2) without any effect on the phosphorylation levels of p38 and JNK. Moreover, similar to curcumin, blockade of pERK1/2 reduced the HG induced apoptosis in pancreatic beta cells. Overexpression of CHOP or siRNA knockdown of PCG-1α counteracted the effect of curcumin on HG induced apoptosis and oxidative stress. These results suggest that curcumin acts through CHOP/PCG-1α and ERK1/2 signaling to block the HG induced oxidative stress and apoptosis.
ISSN:2768-6701

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