Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome

Abstract Substance use disorders are more prevalent in schizophrenia, but the causal links between both conditions remain unclear. Maternal immune activation (MIA) is associated with schizophrenia which may be triggered by stressful experiences during adolescence. Therefore, we used a double-hit rat...

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Bibliographic Details
Main Authors: Roberto Capellán, Javier Orihuel, Alberto Marcos, Marcos Ucha, Mario Moreno-Fernández, Marta Casquero-Veiga, María Luisa Soto-Montenegro, Manuel Desco, Marta Oteo-Vives, Marta Ibáñez-Moragues, Natalia Magro-Calvo, Miguel Ángel Morcillo, Emilio Ambrosio, Alejandro Higuera-Matas
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02378-6