Life Stage-Specific Cargo Receptors Facilitate Glycosylphosphatidylinositol-Anchored Surface Coat Protein Transport in <named-content content-type="genus-species">Trypanosoma brucei</named-content>

Life Stage-Specific Cargo Receptors Facilitate Glycosylphosphatidylinositol-Anchored Surface Coat Protein Transport in <named-content content-type="genus-species">Trypanosoma brucei</named-content>

ABSTRACT The critical virulence factor of bloodstream-form Trypanosoma brucei is the glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG). Endoplasmic reticulum (ER) exit of VSG is GPI dependent and relies on a discrete subset of COPII machinery (TbSec23.2/TbSec24.1). In ot...

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Bibliographic Details
Main Authors: Emilia K. Kruzel, George P. Zimmett, James D. Bangs
Format: Article
Language:English
Published: American Society for Microbiology 2017-08-01
Series:mSphere
Subjects:
COPII
ER exit
GPI anchor
Trypanosoma
cargo receptor
p24
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00282-17

Internet

https://journals.asm.org/doi/10.1128/mSphere.00282-17

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