ALK upregulates POSTN and WNT signaling to drive neuroblastoma

ALK upregulates POSTN and WNT signaling to drive neuroblastoma

Summary: Neuroblastoma is the most common extracranial solid tumor of childhood. While MYCN and mutant anaplastic lymphoma kinase (ALKF1174L) cooperate in tumorigenesis, how ALK contributes to tumor formation remains unclear. Here, we used a human stem cell-based model of neuroblastoma. Mis-expressi...

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Bibliographic Details
Main Authors: Miller Huang, Wanqi Fang, Alvin Farrel, Linwei Li, Antonios Chronopoulos, Nicole Nasholm, Bo Cheng, Tina Zheng, Hiroyuki Yoda, Megumi J. Barata, Tania Porras, Matthew L. Miller, Qiqi Zhen, Lisa Ghiglieri, Lauren McHenry, Linyu Wang, Shahab Asgharzadeh, JinSeok Park, W. Clay Gustafson, Katherine K. Matthay, John M. Maris, William A. Weiss
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002559

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http://www.sciencedirect.com/science/article/pii/S2211124724002559

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