Metabolic Profiling as a Screening Tool for Cytotoxic Compounds: Identification of 3-Alkyl Pyridine Alkaloids from Sponges Collected at a Shallow Water Hydrothermal Vent Site North of Iceland

Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based metabolomics approach was used to determine the che...

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Main Authors: Eydis Einarsdottir, Manuela Magnusdottir, Giuseppe Astarita, Matthias Köck, Helga M. Ögmundsdottir, Margret Thorsteinsdottir, Hans Tore Rapp, Sesselja Omarsdottir, Giuseppe Paglia
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/15/2/52