Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis via the MKP-1/MAPK signaling pathway in neonatal rats

Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis via the MKP-1/MAPK signaling pathway in neonatal rats

Glutamine (Gln) is an immunomodulatory protein that mediates oxidative stress, inflammation, and apoptosis, but has not been reported in the treatment of hyperoxia (Hyp)-induced brain injury. The aim of this study was to determine whether Gln could improve hyp-induced brain injury in neonatal rats t...

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Bibliographic Details
Main Authors: Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
glutamine
hyperoxia
hippocampus
learning and memory impairment
inflammation
MKP-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1096309/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1096309/full

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