Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway

Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of low back pain (LBP), which causes an enormous socioeconomic burden. Previous studies demonstrated that the apoptosis of nucleus pulposus (NP) cells and the dyshomeostasis of extracellular matrix (ECM) contribute...

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Bibliographic Details
Main Authors: Dong Wang, Xin He, Di Wang, Pandi Peng, Xiaolong Xu, Bo Gao, Chao Zheng, Han Wang, Haoruo Jia, Qiliang Shang, Zhen Sun, Zhuojing Luo, Liu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
quercetin
oxidative stress
intervertebral disc degeneration
autophagy
SIRT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.613006/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.613006/full

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