Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids

Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids

Baicalin is a small molecule medication used to treat hepatitis. Our research group discovered that administering baicalin orally to mice following fecal microbiota transplantation from patients resistant to ICIs supported anti-PD-1 activity. However, the precise mechanisms behind this effect are pr...

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Bibliographic Details
Main Authors: Zhang Yu, Liu Xiaojia, Zhao Wei, Zhang Jian, Wang Aiting, Wang Jing, Yang Lin, Cao Bangwei, Yan Dan
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Pharmacological Research
Subjects:
Gut microbiota
Baicalin
PD-1 monoclonal antibody
Short-chain fatty acids (SCFAs)
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003894

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http://www.sciencedirect.com/science/article/pii/S1043661823003894

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