Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes

ABSTRACT Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by heterochromatin. In contrast, we found that early herpes simplex virus (HSV) genome comp...

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Bibliographic Details
Main Authors: Lindsey Silva, Hyung Suk Oh, Lynne Chang, Zhipeng Yan, Steven J. Triezenberg, David M. Knipe
Format: Article
Language:English
Published: American Society for Microbiology 2012-03-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00300-11