Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization

Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization

NK cells are the first line of defense against viruses and malignant cells, and their natural functionality makes these cells a promising candidate for cancer cell therapy. The genetic modifications of NK cells, allowing them to overcome some of their inherent limitations, such as low proliferative...

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Bibliographic Details
Main Authors: Maria A. Streltsova, Maria O. Ustiuzhanina, Eugene V. Barsov, Sofya A. Kust, Rodion A. Velichinskii, Elena I. Kovalenko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
NK cells
genetic modification
cancer cell therapy
K562-mbIL21
retroviral vectors
transduction
Online Access:https://www.mdpi.com/2227-9059/9/6/662

Internet

https://www.mdpi.com/2227-9059/9/6/662

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