Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Abstract Background Although the chondroprotection of peroxisome proliferator-activated receptor α (PPARα) activation against osteoarthritis (OA) has been revealed, the regulatory mechanism of PPARα deficiency to aggravate osteoarthritic cartilage deterioration remains unclear. Here, we aimed to inv...

Full description

Bibliographic Details
Main Authors: Yang Zhou, Li Li, Xiaolei Chen, Qiubo Zhao, Ning Qu, Bing Zhang, Xin Jin, Chun Xia
Format: Article
Language:English
Published: BMC 2023-09-01
Series:European Journal of Medical Research
Subjects:
PPARα deficiency
Autophagy
ERK and Akt activation
Mouse model of experimental OA
Human OA chondrocytes
Online Access:https://doi.org/10.1186/s40001-023-01267-4

Internet

https://doi.org/10.1186/s40001-023-01267-4

Similar Items