Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.

Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.

MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including Rett Syndrome and autism. Altered expression of the two MeCP2 isoforms, MeCP2E1 and MeCP2E2 has been implicated in neurological complications....

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Carl O Olson, Robby M Zachariah, Chinelo D Ezeonwuka, Vichithra R B Liyanage, Mojgan Rastegar
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Public Library of Science (PLoS) 2014-01-01
Sarja:PLoS ONE
Linkit:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090645&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090645&type=printable

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