Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

The design and development of analgesics with mixed-opioid receptor interactions has been reported to decrease side effects, minimizing respiratory depression and reinforcing properties to generate safer analgesic therapeutics. We synthesized bis-cyclic guanidine heterocyclic peptidomimetics from re...

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Bibliographic Details
Main Authors: Jay P. McLaughlin, Ramanjaneyulu Rayala, Ashley J. Bunnell, Mukund P. Tantak, Shainnel O. Eans, Khadija Nefzi, Michelle L. Ganno, Colette T. Dooley, Adel Nefzi
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
heterocyclic peptidomimetics
combinatorial chemistry
solid-phase synthesis
opioid receptors
multifunctional opioid agonist
antinociception
Online Access:https://www.mdpi.com/1422-0067/23/17/9623

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https://www.mdpi.com/1422-0067/23/17/9623

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