Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Abstract Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins, and water. BBB breakdown and extravas...

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Bibliographic Details
Main Authors: Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Monoacylglycerol lipase
2-arachidonoylglycerol
Neuroinflammation
Blood-brain barrier
Neurovasculature
Online Access:http://link.springer.com/article/10.1186/s12974-018-1166-9

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http://link.springer.com/article/10.1186/s12974-018-1166-9

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