DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

Abstract To date, most studies on the DNA polymerase, POLD1, have focused on the effect of POLD1 inactivation mutations in tumors. However, the implications of high POLD1 expression in tumorigenesis remains elusive. Here, we determine that POLD1 has a pro-carcinogenic role in bladder cancer (BLCA) a...

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Bibliographic Details
Main Authors: Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao, Xinghuan Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38160-x

Internet

https://doi.org/10.1038/s41467-023-38160-x

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