Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines

We have determined the effects of the IGF-1R tyrosine kinase inhibitors BMS-754807 (BMS) and OSI-906 (OSI) on cell proliferation and cell-cycle phase distribution in human colon, pancreatic carcinoma, and glioblastoma cell lines and primary cultures. IGF-1R signaling was blocked by BMS and OSI at eq...

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Main Authors: María Fuentes-Baile, María P. Ventero, José A. Encinar, Pilar García-Morales, María Poveda-Deltell, Elizabeth Pérez-Valenciano, Víctor M. Barberá, Javier Gallego-Plazas, Álvaro Rodríguez-Lescure, José Martín-Nieto, Miguel Saceda
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/12/12/3717