Quantifying the relationship and contribution of mitochondrial respiration to systemic exercise limitation in heart failure

Quantifying the relationship and contribution of mitochondrial respiration to systemic exercise limitation in heart failure

Abstract Aims Heart failure with reduced ejection fraction (HFrEF) induces skeletal muscle mitochondrial abnormalities that contribute to exercise limitation; however, specific mitochondrial therapeutic targets remain poorly established. This study quantified the relationship and contribution of dis...

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Bibliographic Details
Main Authors: Pim Knuiman, Sam Straw, John Gierula, Aaron Koshy, Lee D. Roberts, Klaus K. Witte, Carrie Ferguson, Thomas Scott Bowen
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:ESC Heart Failure
Subjects:
Exercise
HFrEF
Lactate threshold
Skeletal muscle
V̇O2peak
Online Access:https://doi.org/10.1002/ehf2.13272

Internet

https://doi.org/10.1002/ehf2.13272

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