A new synthetic ultrasound-assisted method for dibenzoepines

A new synthetic ultrasound-assisted method for dibenzoepines

In this study, we have developed a new ultrasonic synthesis method of dibenzoepines using olanzapine and quetiapine, which are well-known drugs for the treatment of schizophrenia and bipolar disorder. The method is based on the N-alkylation reaction of the piperazine fragment in tricyclic compounds...

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Bibliographic Details
Main Authors: Jolanta Jaśkowska, Anna Karolina Drabczyk, Damian Kułaga, Przemysław Zaręba, Zbigniew Majka, Przemysław Jodłowski
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
Ultrasound-assisted synthesis
Dibenzoazepine
Phase transfer catalysis
N-alkylation
Olanzapine
Quetiapine
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023055275

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http://www.sciencedirect.com/science/article/pii/S2405844023055275

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