Gene knockdown by structure defined single-stem loop small non-coding RNAs with programmable regulatory activities

Gene knockdown by structure defined single-stem loop small non-coding RNAs with programmable regulatory activities

Gene regulation by trans-acting small RNAs (sRNAs) has considerable advantages over other gene regulation strategies. However, synthetic sRNAs mainly take natural sRNAs (MicC or SgrS) as backbones and comprise three functional elements folding into two or more stem-loop structures: an mRNA base pair...

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Bibliographic Details
Main Authors: Yang Wang, Guobin Yin, Huanjiao Weng, Luyao Zhang, Guocheng Du, Jian Chen, Zhen Kang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Regulatory RNA
Metabolic engineering
Synthetic biology
De novo design
Ergothioneine
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X22001193

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http://www.sciencedirect.com/science/article/pii/S2405805X22001193

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