Utilizing an Endogenous Progesterone Receptor Reporter Gene for Drug Screening and Mechanistic Study in Endometrial Cancer

Utilizing an Endogenous Progesterone Receptor Reporter Gene for Drug Screening and Mechanistic Study in Endometrial Cancer

Expression of progesterone receptor (PR) is a favorable prognostic marker for multiple solid tumors. However, PR expression is reduced or lost in malignant tumors. Thus, monitoring and restoring functional PR expression is important in order to sensitize tumor cells to progesterone therapy in endome...

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Bibliographic Details
Main Authors: Yiyang Li, Wei Zhou, Xiangbing Meng, Sarina D. Murray, Long Li, Abby Fronk, Vanessa J. Lazaro-Camp, Kuo-kuang Wen, Meng Wu, Adam Dupuy, Kimberly K. Leslie, Shujie Yang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
progesterone receptor
mCherry
reporter gene
endometrial cancer
high throughput screening
GeCKO library
Online Access:https://www.mdpi.com/2072-6694/14/19/4883

Internet

https://www.mdpi.com/2072-6694/14/19/4883

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