Possibility for Transcriptional Targeting of Cancer-Associated Fibroblasts—Limitations and Opportunities

Possibility for Transcriptional Targeting of Cancer-Associated Fibroblasts—Limitations and Opportunities

Cancer-associated fibroblasts (CAF) are attractive therapeutic targets in the tumor microenvironment. The possibility of using CAFs as a source of therapeutic molecules is a challenging approach in gene therapy. This requires transcriptional targeting of transgene expression by cis-regulatory elemen...

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Bibliographic Details
Main Authors: Dina V. Antonova, Marina V. Zinovyeva, Liya G. Kondratyeva, Alexander V. Sass, Irina V. Alekseenko, Victor V. Pleshkan
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
transcriptional targeting
promoter
tumor microenvironment
fibroblasts
gene therapy
Online Access:https://www.mdpi.com/1422-0067/22/7/3298

Internet

https://www.mdpi.com/1422-0067/22/7/3298

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