Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity

Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity

Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation and tumorigenesis. Autophagy has emerged as a potential mechanism involved in the acquired resistance to anti-EGFR treatments, however, the molecular mechanisms has not been fully addressed. In this study, we identifi...

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Bibliographic Details
Main Authors: Cefan Zhou, Xueying Dong, Ming Wang, Xuehong Qian, Miao Hu, Kai Liang, Yanyan Liang, Rui Zhang, Yuan Huang, Hao Lyu, Shuai Xiao, Yongfei Tang, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Cell Insight
Subjects:
STYK1
EGFR
Autophagy initiation
Resistance
NSCLC
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892722000426

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http://www.sciencedirect.com/science/article/pii/S2772892722000426

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