The lactate receptor HCAR1: A key modulator of epileptic seizure activity
Summary: Epilepsy affects millions globally with a significant portion exhibiting pharmacoresistance. Abnormal neuronal activity elevates brain lactate levels, which prompted the exploration of its receptor, the hydroxycarboxylic acid receptor 1 (HCAR1) known to downmodulate neuronal activity in phy...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-05-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224009015 |