Safety of intranasal insulin administration in patients undergoing cardiovascular surgery: An open-label, nonrandomized, dose-escalation studyCentral MessagePerspective

Safety of intranasal insulin administration in patients undergoing cardiovascular surgery: An open-label, nonrandomized, dose-escalation studyCentral MessagePerspective

Objective: This study aimed to determine the maximum safe dose of intranasal insulin administration during cardiac surgery. Methods: This open-label, Phase 1, single-center, dose-escalation clinical trial recruited patients scheduled to undergo elective cardiac surgery or major vascular surgery requ...

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Bibliographic Details
Main Authors: Yosuke Nakadate, MD, PhD, Akiko Kawakami, MD, PhD, Takeshi Oguchi, MD, PhD, Keisuke Omiya, MD, PhD, Hiroyuki Nakajima, MD, PhD, Hiroshi Yokomichi, MD, PhD, DPH, Hiroaki Sato, MD, PhD, Thomas Schricker, MD, PhD, Takashi Matsukawa, MD, PhD
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:JTCVS Open
Subjects:
cardiac surgery
hypoglycemia
intranasal insulin administration
serum insulin concentration
postoperative delirium
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273623004175

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http://www.sciencedirect.com/science/article/pii/S2666273623004175

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