Inference of gene-phenotype associations via protein-protein interaction and orthology.

One of the fundamental goals of genetics is to understand gene functions and their associated phenotypes. To achieve this goal, in this study we developed a computational algorithm that uses orthology and protein-protein interaction information to infer gene-phenotype associations for multiple speci...

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Bibliographic Details
Main Authors: Panwen Wang, Wing-Fu Lai, Mulin Jun Li, Feng Xu, Hari Krishna Yalamanchili, Robin Lovell-Badge, Junwen Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3806783?pdf=render