PEEP application during mechanical ventilation contributes to fibrosis in the diaphragm

PEEP application during mechanical ventilation contributes to fibrosis in the diaphragm

Abstract Background Positive end-expiratory airway pressure (PEEP) is a potent component of management for patients receiving mechanical ventilation (MV). However, PEEP may cause the development of diaphragm remodeling, making it difficult for patients to be weaned from MV. The current study aimed t...

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Bibliographic Details
Main Authors: Xiaoli Qian, Ye Jiang, Jianwei Jia, Weimin Shen, Yuejia Ding, Yuhan He, Peifeng Xu, Qing Pan, Ying Xu, Huiqing Ge
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Respiratory Research
Subjects:
Mechanical ventilation
Diaphragm dysfunction
Fibrosis
Collagen
TGF-β1
Online Access:https://doi.org/10.1186/s12931-023-02356-y

Internet

https://doi.org/10.1186/s12931-023-02356-y

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