Impact of reduced antibiotic treatment duration on antimicrobial resistance in critically ill patients in the randomized controlled SAPS-trial

Impact of reduced antibiotic treatment duration on antimicrobial resistance in critically ill patients in the randomized controlled SAPS-trial

BackgroundIn the previously reported SAPS trial (https://clinicaltrials.gov/ct2/show/NCT01139489), procalcitonin-guidance safely reduced the duration of antibiotic treatment in critically ill patients. We assessed the impact of shorter antibiotic treatment on antimicrobial resistance development in...

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Bibliographic Details
Main Authors: Arezoo Shajiei, Matthijs S. Berends, Christian F. Luz, Jos A. van Oers, Hermie J. M. Harmsen, Piet Vos, Rob Klont, Bert G. Loef, Auke C. Reidinga, Laura Bormans-Russell, Kitty Linsen, Tom Dormans, Martine Otten, Akke van der Bij, Albertus Beishuizen, Dylan W. de Lange, Evelien de Jong, Maarten W. Nijsten
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Medicine
Subjects:
antibiotics
antimicrobial resistance
procalcitonin
treatment duration
culture
randomized trial
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1080007/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1080007/full

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