Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics

Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics

Pyroptosis provides a new window for relieving the tumor immunosuppressive microenvironment (TIM) and promoting systemic immune responses for tumor treatments. However, gasdermin D (GSDMD), a key protein in the pyroptosis process mediated by caspase-1, is low expressed in the majority of tumor cells...

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Bibliographic Details
Main Authors: Qiang Niu, Yu Liu, Yujing Zheng, Ziwei Tang, Yuna Qian, Ruogu Qi, Jianliang Shen, Ping Zhao
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Self-assembled nanoparticle
Pyroptosis
NLRP3
GSDMD
Inflammation
IL-8
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522004543

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http://www.sciencedirect.com/science/article/pii/S2211383522004543

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