Rejuvenating bone marrow hematopoietic reserve prevents regeneration failure and hepatic decompensation in animal model of cirrhosis

Rejuvenating bone marrow hematopoietic reserve prevents regeneration failure and hepatic decompensation in animal model of cirrhosis

Background and aimBone marrow stem cells (BM-SCs) and their progeny play a central role in tissue repair and regeneration. In patients with chronic liver failure, bone marrow (BM) reserve is severally compromised and they showed marked defects in the resolution of injury and infection, leading to li...

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Main Authors: Nidhi Nautiyal, Deepanshu Maheshwari, Dhananjay Kumar, E. Pranshu Rao, Dinesh Mani Tripathi, Sandeep Kumar, Sunidhi Diwakar, Manisha Bhardwaj, Sujata Mohanty, Prakash Baligar, Anupama Kumari, Chhagan Bihari, Subhrajit Biswas, S. K. Sarin, Anupam Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
chronic liver injury
regeneration failure
hematopoietic stem cells
hepatic decompensation
kupffer cells
cirrhosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439510/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439510/full

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