Participation of neuronal nitric oxide synthase in experimental neuropathic pain induced by sciatic nerve transection

Participation of neuronal nitric oxide synthase in experimental neuropathic pain induced by sciatic nerve transection

Nerve injury leads to a neuropathic pain state that results from central sensitization. This phenomenom is mediated by NMDA receptors and may involve the production of nitric oxide (NO). In this study, we investigated the expression of the neuronal isoform of NO synthase (nNOS) in the spinal cord of...

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Bibliographic Details
Main Authors: M. Chacur, R.J.B. Matos, A.S. Alves, A.C. Rodrigues, V. Gutierrez, Y. Cury, L.R.G. Britto
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-04-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Allodynia
Neuropathic pain
Neuronal nitric oxide synthase
Peripheral neuropathy
Sciatic nerve transection
Spinal cord
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400008

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