Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro

Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro

BackgroundNeutrophils, key players of the immune system, also promote tumor development through the formation of neutrophil extracellular traps (NETs) in a process called NETosis. NETs are extracellular networks of DNA, histones and cytoplasmic and granular proteins (calprotectin, myeloperoxidase, e...

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Bibliographic Details
Main Authors: Raquel Herranz, Julia Oto, Marta Hueso, Emma Plana, Fernando Cana, María Castaño, Lourdes Cordón, David Ramos-Soler, Santiago Bonanad, César D. Vera-Donoso, Manuel Martínez-Sarmiento, Pilar Medina
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
biomarkers
bladder cancer
DNaseI
Dornase alfa
FFPE tissue
NETs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171065/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171065/full

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