Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain

Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain

Abstract Background Ischemic stroke in white matter of the brain induces not only demyelination, but also neuroinflammation. Peripheral T lymphocytes, especially regulatory T cells (Tregs), are known to infiltrate into ischemic brain and play a crucial role in modulation of inflammatory response the...

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Bibliographic Details
Main Authors: Bin Xu, Hiroya Shimauchi-Ohtaki, Yuhei Yoshimoto, Tetsushi Sadakata, Yasuki Ishizaki
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Demyelination
Cell transplantation
iPS cells
Endothelial cells
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-023-02694-0

Internet

https://doi.org/10.1186/s12974-023-02694-0

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